James, who was averaging 9.9 yards per carry in his first two games of the season, injured his knee in TCU's game against Kansas but only represents one piece of the supremely tough squad that the Frogs have at their disposal. In fact, they may hardly notice the loss, shifting in fellow star running back Matthew Tucker in James' absence.
Virginia will have their work cut out for them getting through a TCU defense that has only allowed 6 points in their first two games. The Cavaliers have struggled to put points on the board in their last two games, putting 17 up on Penn State and then only scoring 20 during their big loss to Georgia Tech.
TCU took a 30-14 win the last time the two teams met back in 2009.
Game time, TV channel: 11 a.m. CT, ESPN
Point spread: TCU favored by 14.5 points.
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