Manning will miss tight end Jake Ballard, who has developed into a reliable safety valve, but is out with a knee injury. And he won't have Ahmad Bradshaw, Hakeem Nicks, or Mario Manningham at tip-top shape, either: all are probable with various injuries.
This could mean that Manning relies more heavily than usual on Victor Cruz, who has set secondaries ablaze for much of 2011.
Here's the rest of the Giants injury report for Week 17:
OUT: TE Jake Ballard (knee), LB Mark Herzlich (ankle).
QUESTIONABLE: DE Osi Umenyiora (ankle).
PROBABLE: RB Ahmad Bradshaw (foot), WR Hakeem Nicks (hamstring), WR Mario Manningham (knee).